When Sirtuins and NF-κB Collide
نویسنده
چکیده
Both the sirtuins and certain transcription factors of the NF-kappaB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-kappaB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.
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ورودعنوان ژورنال:
- Cell
دوره 136 شماره
صفحات -
تاریخ انتشار 2009